TECHNICAL INFORMATION BULLETIN
Thermo Scientific
™
SampleManager
LIMS
™
and Thermo Scientific
™
Chromeleon
™
CDS Link
Find out more at thermofisher.com/LIMS
Key Words
Integrated LIMS and CDS, Secure & Compliant Interface,
Workows to Drive the Lab Process, Multi-Vendor Instrument Support,
Centralized Chromatography & Mass Spectroscopy Data Processing
& Management, Sophisticated Data Visualization, Paperless Lab
SampleManager LIMS delivers the most complete Informatics
solution available, including functionality for method execution,
laboratory and scientific data management. Built into the latest
version of SampleManager and unique to Thermo Fisher Scientific,
are LIMS, SDMS and LES functionality on one platform, saving lab
managers the time and expense of purchasing and maintaining
software from multiple suppliers. SampleManager LIMS is also fully
integrated with Chromeleon CDS, providing a seamless CDS link
within the LIMS to streamline the lab process and eliminate manual
steps related to sample testing and results capture and analysis.
The integration of SampleManager LIMS with Chromeleon CDS
gives users access to all LC, GC, IC and MS data within the same
platform and user environment, simplifying training of personnel
and reducing operating costs.
Both SampleManager LIMS and Chromeleon CDS deliver workflow
capabilities so the system is simple to manage and maintain
without relying on external IT or programming resources.
Unique to the SampleManager LIMS and Chromeleon CDS
link, users will have full capability to monitor queue status and
instrument health from the LIMS, giving users the ability to assign
work more effectively and allow for instrument maintenance as
required. The instrument notifies users of impending service,
allowing the lab to schedule workload more effectively and
improve instrument utilization. The instrument notifies users of
potential wear part failure, allowing the lab to schedule instrument
maintenance at the most convenient time and improving instrument
uptime. Information is stored in the instrument firmware, ensuring
The Chromeleon link options are available
from the top menu bar on the home page,
as well as via a convenient Explorer Cabinet
where all Chromeleon Link-related data and
options can be found.
thermo scientific
data is recorded and maintained at all times, even if a module is
moved/exchanged. The SampleManager LIMS and Chromeleon
CDS link gives users an out-of-the-box interface supported by one
company that combines workflows that drive the lab process all
the way from sample reception through to reporting.
Chromeleon CDS is the leader in chromatography data systems
software, unifying workflows for chromatography and routine
quantitative MS analysis, providing full integration of Thermo
Scientific gas chromatography (GC)-MS/MS and liquid
chromatography (LC)-MS/MS instruments. Chromeleon CDS
allows you to run your analyses in an enterprise environment –
from method creation to quantitation and library-based compound
identification and offers industry-leading multi-vendor control,
supporting over 400 different instrument modules from over 15
manufacturers.
With the SampleManager LIMS and Chromeleon CDS link
built onto one platform, users will have complete control of all
chromatography and/or mass spec instruments, combining two
of the most common analytical techniques into a single system.
SampleManager LIMS then allows you to turn that data into
actionable knowledge by providing sophisticated data processing,
visualization, search and data mining capabilities.
Thermo Scientific Chromeleon CDS is a leading
chromatography data system, unifying workflows for
chromatography and routine quantitative MS analysis
Integration = data integrity, quality and productivity
A typical lab will utilize multiple systems, such as LIMS, CDS, LES, SDMS, spreadsheets and some paper-based methods. In this non-
integrated environment, multiple steps must be taken to accomplish any given task, from pulling a sample, entering sample lists and
analysis in the lab notebook, updating the CDS log, manually transferring results to a spreadsheet to do further calculations, approving
those calculations and re-entering them in a lab notebook or into the LIMS.
Chromeleon CDS is particularly good at preparing calculations, something most CDS systems are incapable of doing. Once Chromeleon
CDS is validated, the automated calculations engine gives you validated results. No spreadsheet is necessary, saving time entering and
approving results manually into a spreadsheet. And because results calculation is available and validated within either SampleManager LIMS
or Chromeleon CDS, your workflow is optimally automated and secure, giving your lab more opportunities to save time and money, and generate
secure and reliable data.
Integrating LIMS and CDS allows the lab to effectively remove eight manual processes, giving you one streamlined automated
process – leaving only one manual process – putting the sample into the instrument and hitting the “GO” button.
Workflows to drive the laboratory process
Comprehensive multi-vendor instrument support
Both SampleManager and Chromeleon leverage workflow capabilities to provide a simple system to manage and maintain without
relying on external IT or programming resources. Workflows give end users an easy way to step through their process, ensuring
quality processes are followed. Workflow capabilities include passing information to and from other systems acting as a bridge between
SampleManager and Chromeleon at user decision points. The end user decides when data is ready to pass from one system to the next
either by manually triggering the handover or, more often, by defining the handover points in the workflow.
In a Chromeleon installation, over 400 instruments from 15 vendors are automatically found in the network. Chromeleon controls
Thermo Scientific Instruments, like ICs, LCs and the ASE-350, as well as LCs and GCs from other vendors like Agilent, Waters,
Perkin Elmer and Shimadzu, using the intuitive ePanel sets.
Comprehensive multi-vendor instrument support
Centralized Data Management
SampleManager LIMS can do more than just submit runs and receive those results from Chromeleon CDS. The LIMS can also
access and manage information like instrument calibration and maintenance schedules, preventing users from accessing instruments that
are out of calibration and potentially wasting time and valuable samples.
One of the key advantages of Chromeleon 7.2 is that it allows users to access LC, GC, IC, and MS data all within the same platform
and user environment. Mass Spectrometry provides enormous qualitative and quantitative information about samples and it is becoming
commonplace in quality control testing. Managing all of the chromatography and mass spectroscopy instrumentation in a single solution
simplifies training and support and reduces operating costs.
Interactive charts for data review
Advanced search & data mining: SDMS
Chromeleon 7.2 enables users to manage samples and perform trend analysis by instrument, by operator, or by lab for a user
defined period of time.
Comprehensive data mining tools allow each user to search for specific sample or compound information across runs. When
linked to SampleManager LIMS, users can search on the batch or lot information to return all samples, across any instrument throughout the
workflow. Because SDMS functionality is built into SampleManager LIMS, all instrument results are available within the LIMS - whether it’s
chromatography or FTIR data, equipment files or unstructured data like XML, Text or PDF files - SampleManager LIMS with built in SDMS
functionality can give you access to any data at any time. Once that data is found, it can be stacked, overlaid, reported and visualized in 3D,
giving users rapidly configured sophisticated, paperless review and approval procedures.
Advanced search & data mining
Monitoring instrument health
Once the data is returned to the LIMS, SampleManager has sophisticated data mining tools to review the chromatography and
mass spectroscopy data in the context of all of the product, batch or lot, and sample information, giving the lab a complete
overview and showing when processes are drifting towards nonconformance. Interactive dashboards allow lab managers to
drill down and discover root causes of any issues that do occur and optimize their process to prevent future issues.
Unique to SampleManager LIMS and the Chromeleon CDS link, users now have full capability to monitor queue status and
instrument health from the LIMS, enabling you to manage workflow more effectively and allow for instrument maintenance or
service as required. It is important to know when a column needs to be replaced before it results in failed separation or poor
peak formation.
The instrument notifies users of impending service, allowing users to schedule workload more effectively, and improve instrument
utilization. The instrument notifies user of potential wear part failure, allowing the user to schedule instrument maintenance at
most convenient time and improving instrument uptime. Information is stored in instrument firmware ensuring that data is recorded and
maintained at all times, even if module is moved/exchanged, which ensures compliance.
SampleManager LIMS and Chromeleon CDS
The new SampleManager LIMS and Chromeleon CDS link gives
users an out-of-the-box interface supported by one company that
combines workflows that drive the lab process all the way from
sample reception through to reporting. Chromeleon CDS is the
leader in chromatography data systems software, unifying
workflows for chromatography and routine quantitative MS
analysis, providing full integration of Thermo Scientific gas
chromatography (GC)-MS/MS and liquid chromatog-raphy
(LC)-MS/MS instruments. Chromeleon CDS allows you to run
your analyses in an enterprise environment – from method creation
to quantitation and library-based compound identification and
offers industry-leading multi-vendor control, supporting over
400 different instrument modules from over 15 manufacturers.
Now that Chromeleon CDS is linked to SampleManager LIMS,
users have complete control of all chromatography and mass
spec instruments, combining two of the most common analytical
techniques into a single system. SampleManager LIMS then allows
you to turn that data into actionable knowledge by providing
sophisticated data processing, visualization, search and data
mining capabilities.
Integrating the Lab for Efficiency,
Productivity and Compliance
CONNECTS for the Paperless Lab delivers the methodology,
technology and services necessary to transform today’s
laboratories into tightly integrated paperless environments,
while leveraging existing investments in software systems,
databases and laboratory instrumentation from a wide variety
of commercial vendors.
By bridging the islands of data generated in the lab and
transforming that data into information that can be used across the
enterprise, organizations will reap the benefits of improved access
to real-time information, regulatory compliance, data integrity,
as well as time and cost savings by automating processes and
reducing manual data handling.
CONNECTS for the Paperless Lab is comprised of three unique
components — methodology, technology and services — that
combined deliver seamless and continuous data flows from the
lab into the enterprise, improving results analysis, enabling faster
decision making and improving productivity.
Building on a history of informatics innovations, CONNECTS
provides access to all instrument data via a single interface
and allows real-time analysis and investigation of results. The
technology converts raw data to a vendor independent XML
storage format to ensure future proof data archiving and facilitate
data and information sharing across the organization, without
having to rely on access to the original application. CONNECTS
technology acts as a ‘translator’ of all the individual languages of
the lab’s disparate instruments and is able to deliver and accept
data in the format appropriate for each instrument.
Lab
Workflow
Data
Visualization
Business
Intelligence
Instruments
Enterprise
Integration
Samples,
Tests &
Results
Chromeleon
Integration
Stability
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A Paperless Lab has taken advantage of opportunities to integrate the laboratory with the enterprise and automates systems by
eliminating paper-based, manual and error-prone processes. While most companies have invested in many instruments and software solutions
in the laboratory, manufacturing and the enterprise to improve operations, these systems are not seamlessly integrated, creating data silos, or
standalone information repositories that do not communicate with one another. By automating operations and integrating these individual solutions,
organizations can reduce paperwork, increase efficiency and throughput, automate regulatory compliance, reduce costs, foster collaboration and
make faster, better informed business decisions.
Find out more at thermofisher.com/LIMS
©2016 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries
unless otherwise specified. This information is presented as an example of the capabilities of Thermo Fisher Scientific Inc. products. It is not
intended to encourage use of these products in any manners that might infringe the intellectual property rights of others. Specifications, terms
and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details.
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Just how costly are your current operations?
This chart illustrates how much time is spent on analysis vs.
administrative tasks in a typical laboratory. Reducing the
amount of time spent on manual or paper-based reporting and
documentation can save time and money for your lab operations.
By automating the laboratory, your organization can improve
efficiency, productivity, quality and reduce costs. The goal is to
spend more time doing Analytical Work and less in Documentation
and Checks. What would you do with the time saved?
Planning of analysis
Prepare documentation
Prepare analysis
Prepare reagents
Document reagent preparation
Maintain logbook
Create sequence
Execute SST
Execute run
Document run/values
Calculations
Transcribe end result
Close out analysis by lab tech.
Check run
Laboratory head review
Close out
Additional check
Copy raw data
Place doc. in storage
0.0% 2.0% 4.0% 6.0% 8.0% 10.0% 12.0% 14.0% 16.0% 18.0%
Analytical work Documentation Checks
